OMGWTF, Dr. Hojo is in it. No, I'm not kidding. There actually is a Dr. Hojo in this game with much the same personality, but with shorter hair and no glasses. He's involved in (what else) genetic modification.
Other random observations: Nikolai is a dead ringer for Rufus, except for his eye color. Yuri has a case of Cloud-weird-in-the-head. Joachim Valentine... Well. He's a vampire, though thankfully the resemblance to Vincent Valentine ends there (Somehow I just can't picture Vincent being as downright weird as Joachim. If I try my brain shuts off from laughing too hard. Joachim is every cheesy superhero in the world combined, plus Major Armstrong from Fullmetal Alchemist).
And now, thanks to these observations, my brain is trying to cross them over. No! Bad brain! I have enough plotbunnies already! I don't need to be thinking about Yuri finding Sephiroth or Cloud in the graveyard and using him for a fusion-
Too late. >_<
Edit: Also, Dr. Hojo is head of the Hojo labs, specialising in weapons development. (He took Scarlet's job? :p)